Promising new treatment targets in patients with fibrosing lung disorders
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10291502" target="_blank" >RIV/00216208:11110/14:10291502 - isvavai.cz</a>
Alternative codes found
RIV/00064190:_____/14:#0000927
Result on the web
<a href="http://dx.doi.org/10.12998/wjcc.v2.i11.668" target="_blank" >http://dx.doi.org/10.12998/wjcc.v2.i11.668</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.12998/wjcc.v2.i11.668" target="_blank" >10.12998/wjcc.v2.i11.668</a>
Alternative languages
Result language
angličtina
Original language name
Promising new treatment targets in patients with fibrosing lung disorders
Original language description
The processes of lung fibrogenesis and fibrotic healing are common to a number of conditions with different etiologies. The lungs are the only affected organ in some cases, whereas in others, several organ systems are involved. Therapeutic options can bediscussed from various perspectives. In this review, we address the localization of therapeutic targets with regard to cell compartments, including secreted ligands, cell surface, plasma membrane-cytosol interplay, cytosol and nucleus. Complex approachusing stem cell therapy is also discussed. As the prognosis of patients with these disorders remains grim, treatment combinations targeting different molecules within the cell should sometimes be considered. It is reasonable to assume that blocking specific pathways will more likely lead to disease stabilization, while stem cell-based treatments could potentially restore lung architecture. Gene therapy could be a candidate for preventive care in families with proven specific gene polymor
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FC - Pneumology
OECD FORD branch
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Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
World Journal of Clinical Cases
ISSN
2307-8960
e-ISSN
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Volume of the periodical
2
Issue of the periodical within the volume
11
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
668-675
UT code for WoS article
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EID of the result in the Scopus database
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