Stem Cell Treatment in Amyotrophic Lateral Sclerosis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F15%3A00459255" target="_blank" >RIV/68378041:_____/15:00459255 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Stem Cell Treatment in Amyotrophic Lateral Sclerosis
Original language description
Amyotrophic lateral sclerosis (ALS) is a largely sporadic progressive neurodegenerative disease affecting upper and lower motor neurons (MNs) and specific etiology that is not completely understood. Up to now, there is no clinically relevant treatment available for ALS. The novel therapeutic strategies should aim at neuroprotection, stimulation of intrinsic neurogenesis and replacement of affected neural cells. These could be achieved by application of powerful modern therapeutic methods such as gene therapy, transplantation of different types of engineered and non-engineered stem cells. Cell-based therapies could facilitate either restoration/substitution or the preservation of MNs. Special attention has been paid to treatment with autologous stem cells, as the most promising approach to the treatment of ALS patients. This review summarises the progress made in translating to the patients' bedside the results achieved from in vivo preclinical studies.
Czech name
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Czech description
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Project
<a href="/en/project/LO1309" target="_blank" >LO1309: Cell Therapy and Tissue Repair</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Book/collection name
From Functionalized Nanostructures Towards Engineered Macrostructures
ISBN
978-80-88113-20-1
Number of pages of the result
13
Pages from-to
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Number of pages of the book
176
Publisher name
Epika
Place of publication
Jindřichův Hradec
UT code for WoS chapter
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