Neuroprotective Potential of Cell-Based Therapies in ALS:From BenchtoBedside

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F17%3A00480127" target="_blank" >RIV/68378041:_____/17:00480127 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/17:10373553

Result on the web

<a href="http://dx.doi.org/10.3389/fnins.2017.00591" target="_blank" >http://dx.doi.org/10.3389/fnins.2017.00591</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fnins.2017.00591" target="_blank" >10.3389/fnins.2017.00591</a>

Result language

angličtina

Original language name

Neuroprotective Potential of Cell-Based Therapies in ALS:From BenchtoBedside

Original language description

Motor neurons (MN) degeneration is a main feature of amyotrophic lateral sclerosis (ALS), a neurological disorder with a progressive course. The diagnosis of ALS is essentially a clinical one. Most common symptoms include a gradual neurological deterioration that reflect the impairment and subsequent loss of muscle functions. Up-to-date ALS has no therapy that would prevent or cure a disease. Modern therapeutic strategies comprise of neuroprotective treatment focused on antiglutamatergic, antioxidant, antiapoptotic, and anti-inflammatory molecules. Stem cells application and gene therapy has provided researchers with a powerful tool for discovery of new mechanisms and therapeutic agents, as well as opened new perspectives for patients and family members. Here, we review latest progress made in basic, translational and clinical stem cell research related to the ALS. We overviewed results of preclinical and clinical studies employing cell-based therapy to treat neurodegenerative disorders. A special focus has been made on the neuroprotective properties of adult mesenchymal stromal cells (MSC) application into ALS patients. Finally, we overviewed latest progress in the field of embryonic and induced pluripotent stem cells used for the modeling and application during neurodegeneration in general and in ALS in particular.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Neuroscience

ISSN

1662-453X

e-ISSN

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Volume of the periodical

11

Issue of the periodical within the volume

oct.

Country of publishing house

CH - SWITZERLAND

Number of pages

15

Pages from-to

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UT code for WoS article

000413530700002

EID of the result in the Scopus database

2-s2.0-85031997325