The role of mesenchymal stromal cells in spinal cord injury, regenerative medicine and possible clinical applications
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F13%3A10209697" target="_blank" >RIV/00216208:11130/13:10209697 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/13:00397685
Result on the web
<a href="http://dx.doi.org/10.1016/j.biochi.2013.08.004" target="_blank" >http://dx.doi.org/10.1016/j.biochi.2013.08.004</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.biochi.2013.08.004" target="_blank" >10.1016/j.biochi.2013.08.004</a>
Alternative languages
Result language
angličtina
Original language name
The role of mesenchymal stromal cells in spinal cord injury, regenerative medicine and possible clinical applications
Original language description
Diseases of the central nervous system still remain among the most challenging pathologies known to mankind, having no or limited therapeutic possibilities and a very pessimistic prognosis. Advances in stem cell biology in the last decade have shown thatstem cells might provide an inexhaustible source of neurons and glia as well as exerting a neuroprotective effect on the host tissue, thus opening new horizons for tissue engineering and regenerative medicine. Here, we discuss the progress made in the cell-based therapy of spinal cord injury. An emphasis has been placed on the application of adult mesenchymal stromal cells (MSCs). We then review the latest and most significant results from in vitro and in vivo research focusing on the regenerative/neuroprotective properties of MSCs. We also attempt to correlate the effect of MSCs with the pathological events that are taking place in the nervous tissue after SCI. Finally, we discuss the results from preclinical and clinical trials invol
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biochimie
ISSN
0300-9084
e-ISSN
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Volume of the periodical
95
Issue of the periodical within the volume
12
Country of publishing house
FR - FRANCE
Number of pages
14
Pages from-to
2257-2270
UT code for WoS article
000327805400008
EID of the result in the Scopus database
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