Proteomic techniques for characterisation of mesenchymal stem cell secretome.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F13%3A00420728" target="_blank" >RIV/67985904:_____/13:00420728 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.biochi.2013.07.015" target="_blank" >http://dx.doi.org/10.1016/j.biochi.2013.07.015</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.biochi.2013.07.015" target="_blank" >10.1016/j.biochi.2013.07.015</a>

Result language

angličtina

Original language name

Proteomic techniques for characterisation of mesenchymal stem cell secretome.

Original language description

Mesenchymal stem cells (MSCs) are multipotent cells with a substantial potential in human regenerative medicine due to their ability to migrate to sites of injury, capability to suppress immune response and accessibility in large amount from patient's own bone marrow or fat tissue. It has been increasingly observed that the transplanted MSCs did not necessarily engraft and differentiate at the site of injury but might exert their therapeutic effects through secreted trophic signals. The MSCs secrete a variety of autocrine/paracrine factors, called secretome, that support regenerative processes in the damaged tissue, induce angiogenesis, protect cells from apoptotic cell death and modulate immune system. The cell culture medium conditioned by MSCs or osteogenic, chondrogenic as well as adipogenic precursors derived from MSCs has become a subject of intensive proteomic profiling in the search for and identification of released factors and microvesicles that might be applicable in regener

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biochimie

ISSN

0300-9084

e-ISSN

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Volume of the periodical

95

Issue of the periodical within the volume

12

Country of publishing house

FR - FRANCE

Number of pages

16

Pages from-to

2196-2211

UT code for WoS article

000327805400002

EID of the result in the Scopus database

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