Characterization of a new human plasma cell leukemia cell line UHKT-944

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10289268" target="_blank" >RIV/00216208:11110/15:10289268 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/15:10289268 RIV/00216208:11210/15:10289268 RIV/00023736:_____/15:00011283 RIV/00064165:_____/15:10289268
Result on the web
<a href="http://dx.doi.org/10.1111/ejh.12505" target="_blank" >http://dx.doi.org/10.1111/ejh.12505</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/ejh.12505" target="_blank" >10.1111/ejh.12505</a>

Result language
angličtina
Original language name
Characterization of a new human plasma cell leukemia cell line UHKT-944
Original language description
A new interleukin-6 (IL-6)-dependent plasma cell leukemia cell line UHKT-944 was established from bone marrow cells derived from a 55-yr-old man with plasma cell leukemia. The cell line possesses phenotypic characteristics of plasma cells including the production of a monoclonal immunoglobulin IgA1-kappa. VH3-9 region of IgVH genes was rearranged and somatically hypermutated. The UHKT-944 cells were found to be negative for most of tested B-cell, T-cell, and myeloid markers. According to cytogenetic analysis, the cells were classified as near tetraploid with several numerical and structural abnormalities including the t(14;20) involving IgH locus. The established permanent plasma cell leukemia cell line is a suitable model for the study of cellular andmolecular mechanisms of pathogenesis of this rare malignant disease.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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