Development and Structural Modifications of Cholinesterase Reactivators against Chemical Warfare Agents in Last Decade: A Review
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10293926" target="_blank" >RIV/00216208:11110/15:10293926 - isvavai.cz</a>
Alternative codes found
RIV/62690094:18470/15:50003444 RIV/00179906:_____/15:10293926
Result on the web
<a href="http://dx.doi.org/" target="_blank" >http://dx.doi.org/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/1389557514666141128102837" target="_blank" >10.2174/1389557514666141128102837</a>
Alternative languages
Result language
angličtina
Original language name
Development and Structural Modifications of Cholinesterase Reactivators against Chemical Warfare Agents in Last Decade: A Review
Original language description
Organophosphate (OP) pesticides and nerve agents are responsible for suicidal and accidental poisonings. The acute toxicity of nerve agents leads to progressive inhibition of the enzyme acetylcholinesterase (AChE) by phosphylation of serine residue at the active site of gorge. The recent massive destruction of Syrian civilians by nerve gas sarin, has again renewed the research attention of global science fraternity towards nerve agents, their mode of action and most prominently their therapeutic treatment. This review is principally focused on nerve agent intoxication. The common approach to deal with OP-intoxication is, application of antimuscarinic drug (atropine), anticonvulsant drug (diazepam) and clinically used oximes (pralidoxime, trimedoxime, obidoxime and asoxime). However, the existing therapeutic approach is arguable and has several failings to cure all kinds of nerve agent poisonings. Considering this issue, numerous oximes have been synthesized and screened through various
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Mini reviews in medicinal chemistry
ISSN
1389-5575
e-ISSN
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Volume of the periodical
15
Issue of the periodical within the volume
1
Country of publishing house
AE - UNITED ARAB EMIRATES
Number of pages
15
Pages from-to
58-72
UT code for WoS article
000350752300008
EID of the result in the Scopus database
2-s2.0-84924965798