The protective effect of hypercapnia on ischemia-reperfusion injury in lungs
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10294595" target="_blank" >RIV/00216208:11110/15:10294595 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/15:10294595 RIV/00064203:_____/15:10294595
Result on the web
<a href="http://dx.doi.org/10.1016/j.resp.2014.10.002" target="_blank" >http://dx.doi.org/10.1016/j.resp.2014.10.002</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.resp.2014.10.002" target="_blank" >10.1016/j.resp.2014.10.002</a>
Alternative languages
Result language
angličtina
Original language name
The protective effect of hypercapnia on ischemia-reperfusion injury in lungs
Original language description
Lifesaving therapy for patients with end-stage lung disease is lung transplantation. However, there are not enough available donors. A relatively new method of transplantation from non-heart-beating donors (NHBDs) allows the treatment of the lung outsidethe body and could increase the number of suitable lungs. We have focused on hypercapnic ventilation, which has the possibility of reducing reactive oxygen species damage. We used four experimental and two control groups of adult rats. Each experimentalgroup underwent the protocol of NHBD lung harvesting. The lungs were than perfused in an ex vivo model and we measured weight gain, arterial-venous difference in partial pressure of oxygen and perfusion pressure. We observed that hypercapnic ventilationduring reperfusion reduces the development of pulmonary oedema and has a protective effect on the oxygen transport ability of the lungs after warm ischemia. The effect of CO2 on pulmonary oedema and on oxygen transport ability after warm
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Respiratory Physiology and Neurobiology
ISSN
1569-9048
e-ISSN
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Volume of the periodical
205
Issue of the periodical within the volume
leden
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
5
Pages from-to
42-46
UT code for WoS article
000347654800007
EID of the result in the Scopus database
2-s2.0-84910072764