Orphan nuclear receptor NR4A1 regulates transforming growth factor-beta signaling and fibrosis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10294722" target="_blank" >RIV/00216208:11110/15:10294722 - isvavai.cz</a>

Alternative codes found

RIV/00023728:_____/15:#0005052

Result on the web

<a href="http://dx.doi.org/10.1038/nm.3777" target="_blank" >http://dx.doi.org/10.1038/nm.3777</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/nm.3777" target="_blank" >10.1038/nm.3777</a>

Result language

angličtina

Original language name

Orphan nuclear receptor NR4A1 regulates transforming growth factor-beta signaling and fibrosis

Original language description

Mesenchymal responses are an essential aspect of tissue repair. Failure to terminate this repair process correctly, however, results in fibrosis and organ dysfunction. Therapies that block fibrosis and restore tissue homeostasis are not yet available forclinical use. Here we characterize the nuclear receptor NR4A1 as an endogenous inhibitor of transforming growth factor-beta (TGF-beta) signaling and as a potential target for anti-fibrotic therapies. NR4A1 recruits a repressor complex comprising SP1, SIN3A, CoREST, LSD1, and HDAC1 to TGF-beta target genes, thereby limiting pro-fibrotic TGF-beta effects. Even though temporary upregulation of TGF-beta in physiologic wound healing induces NR4A1 expression and thereby creates a negative feedback loop, thepersistent activation of TGF-beta signaling in fibrotic diseases uses AKT- and HDAC-dependent mechanisms to inhibit NR4A1 expression and activation. Small-molecule NR4A1 agonists can overcome this lack of active NR4A1 and inhibit experime

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FE - Other fields of internal medicine

OECD FORD branch

—

Project

—

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nature Medicine

ISSN

1078-8956

e-ISSN

—

Volume of the periodical

21

Issue of the periodical within the volume

2

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

150-158

UT code for WoS article

000348974800017

EID of the result in the Scopus database

2-s2.0-84925537240