Heat shock protein 90 (Hsp90) inhibition targets canonical TGF-beta signalling to prevent fibrosis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10284362" target="_blank" >RIV/00216208:11110/14:10284362 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1136/annrheumdis-2012-203095" target="_blank" >http://dx.doi.org/10.1136/annrheumdis-2012-203095</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1136/annrheumdis-2012-203095" target="_blank" >10.1136/annrheumdis-2012-203095</a>
Alternative languages
Result language
angličtina
Original language name
Heat shock protein 90 (Hsp90) inhibition targets canonical TGF-beta signalling to prevent fibrosis
Original language description
Objectives Targeted therapies for systemic sclerosis (SSc) and other fibrotic diseases are not yet available. We evaluated the efficacy of heat shock protein 90 (Hsp90) inhibition as a novel approach to inhibition of aberrant transforming growth factor (TGF)-beta signalling and for the treatment of fibrosis in preclinical models of SSc. Methods Expression of Hsp90 was quantified by quantitative PCR, western blot and immunohistochemistry. The effects of Hsp90 inhibition were analysed in cultured fibroblasts, in bleomycin-induced dermal fibrosis, in tight-skin (Tsk-1) mice and in mice overexpressing a constitutively active TGF-beta receptor I (T beta RI). Results Expression of Hsp90 beta was increased in SSc skin and in murine models of SSc in a TGF-beta-dependent manner. Inhibition of Hsp90 by 17-dimethylaminoethylamino-17-demethoxy-geldanamycin (17-DMAG) inhibited canonical TGF-beta signalling and completely prevented the stimulatory effects of TGF-beta on collagen synthesis and myofib
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FE - Other fields of internal medicine
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Annals of the Rheumatic Diseases
ISSN
0003-4967
e-ISSN
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Volume of the periodical
73
Issue of the periodical within the volume
6
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
1215-1222
UT code for WoS article
000335362100048
EID of the result in the Scopus database
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