Heat shock protein 90 (Hsp90) inhibitors target canonical TGF-? signaling to prevent fibrosis.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023728%3A_____%2F14%3A%230004039" target="_blank" >RIV/00023728:_____/14:#0004039 - isvavai.cz</a>

Result on the web

<a href="http://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=16&SID=R1YSBTEQp1pzDbZIep4&page=1&doc=1" target="_blank" >http://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=16&SID=R1YSBTEQp1pzDbZIep4&page=1&doc=1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1136/annrheumdis-2012-203095" target="_blank" >10.1136/annrheumdis-2012-203095</a>

Result language

angličtina

Original language name

Heat shock protein 90 (Hsp90) inhibitors target canonical TGF-? signaling to prevent fibrosis.

Original language description

Hsp90 is upregulated in SSc and is critical for TGF-? signalling. Pharmacological inhibition of Hsp90 effectively blocks the profibrotic effects of TGF-? in cultured fibroblasts and in different preclinical models of SSc. These results have translationalimplications, as several Hsp90 inhibitors are in clinical trials for other indications

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30226 - Rheumatology

Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ANNALS OF THE RHEUMATIC DISEASES

ISSN

0003-4967

e-ISSN

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Volume of the periodical

73

Issue of the periodical within the volume

6

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

1215-1222

UT code for WoS article

000335362100048

EID of the result in the Scopus database

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