The Nuclear Receptor Constitutive Androstane Receptor/NR1I3 Enhances the Profibrotic Effects of Transforming Growth Factor beta and Contributes to the Development of Experimental Dermal Fibrosis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10285291" target="_blank" >RIV/00216208:11110/14:10285291 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1002/art.38819" target="_blank" >http://dx.doi.org/10.1002/art.38819</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/art.38819" target="_blank" >10.1002/art.38819</a>

Result language

angličtina

Original language name

The Nuclear Receptor Constitutive Androstane Receptor/NR1I3 Enhances the Profibrotic Effects of Transforming Growth Factor beta and Contributes to the Development of Experimental Dermal Fibrosis

Original language description

CAR is upregulated in SSc and regulates TGF-? signaling. Activation of CAR increases the profibrotic effects of TGF-? in cultured fibroblasts and in different preclinical models of SSc. Thus, inactivation of CAR might be a novel approach to target aberrant TGF-? signaling in SSc and in other fibrotic diseases

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FE - Other fields of internal medicine

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Arthritis &amp; Rheumatology

ISSN

2326-5191

e-ISSN

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Volume of the periodical

66

Issue of the periodical within the volume

11

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

3140-3150

UT code for WoS article

000344349500024

EID of the result in the Scopus database

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