Cancer-associated fibroblasts are not formed from cancer cells by epithelial-to-mesenchymal transition in nu/nu mice
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10295077" target="_blank" >RIV/00216208:11110/15:10295077 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/15:00444980
Result on the web
<a href="http://dx.doi.org/10.1007/s00418-014-1293-z" target="_blank" >http://dx.doi.org/10.1007/s00418-014-1293-z</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00418-014-1293-z" target="_blank" >10.1007/s00418-014-1293-z</a>
Alternative languages
Result language
angličtina
Original language name
Cancer-associated fibroblasts are not formed from cancer cells by epithelial-to-mesenchymal transition in nu/nu mice
Original language description
Cancer-associated fibroblasts are bioactive elements influencing the biological properties of malignant tumors. Their origin from different cell types has been established, and the possibility of their formation by epithelial-to-mesenchymal transition from cancer cells is under debate. This study shows that human cancer cells grafted to nu/nu mice induced formation of tumor stroma with the presence of typical smooth muscle actin-containing cancer-associated fibroblasts. These cells seem to be of the host origin because they are not recognized by an antibody specific for human vimentin, as was also verified in vitro. These results suggest that cancer-associated stromal fibroblasts are not formed by epithelial-to-mesenchymal transition from cancer cells.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EA - Morphology and cytology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Histochemistry and Cell Biology
ISSN
0948-6143
e-ISSN
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Volume of the periodical
143
Issue of the periodical within the volume
5
Country of publishing house
DE - GERMANY
Number of pages
7
Pages from-to
463-469
UT code for WoS article
000352652300003
EID of the result in the Scopus database
2-s2.0-84939935866