Analysis of serum anion gap and osmolal gap in diagnosis and prognosis of acute methanol poisoning: clinical study in 86 patients
Result description
We performed a retrospective study in 86 patients from the Czech methanol outbreak in 2012 to determine the role of anion and osmolal gaps in diagnosis and prognosis of methanol poisoning. Methanol and ethanol were measured by a gas chromatographic method with flame ionization detection. Formate was measured enzymatically. Osmolality was measured by freezing point depression method. From 86 patients, 15 died, 47 survived without, and 24 survived with visual/CNS sequelae. There was a statistically significant correlation between the osmolal gap and serum methanol concentrations (R (2) = 0.704; p < 0.001); however, the sensitivity was low for the detection of serum methanol under 20 mmol dm(-3). The survivors without sequelae had lower osmolal gap than those who survived with visual/CNS damage (p = 0.002). The correlation between the anion gap and serum formate on admission was significant (R (2) = 0.28; p < 0.05). The anion gap well correlated with the variables characterizing the sever
Keywords
Toxic alcoholsPrognosisDiagnosticsAcute methanol poisoningOsmolal gapSerum anion gap
The result's identifiers
Result code in IS VaVaI
Alternative codes found
RIV/61388955:_____/15:00443514 RIV/00064165:_____/15:10295078
Result on the web
DOI - Digital Object Identifier
Alternative languages
Result language
angličtina
Original language name
Analysis of serum anion gap and osmolal gap in diagnosis and prognosis of acute methanol poisoning: clinical study in 86 patients
Original language description
We performed a retrospective study in 86 patients from the Czech methanol outbreak in 2012 to determine the role of anion and osmolal gaps in diagnosis and prognosis of methanol poisoning. Methanol and ethanol were measured by a gas chromatographic method with flame ionization detection. Formate was measured enzymatically. Osmolality was measured by freezing point depression method. From 86 patients, 15 died, 47 survived without, and 24 survived with visual/CNS sequelae. There was a statistically significant correlation between the osmolal gap and serum methanol concentrations (R (2) = 0.704; p < 0.001); however, the sensitivity was low for the detection of serum methanol under 20 mmol dm(-3). The survivors without sequelae had lower osmolal gap than those who survived with visual/CNS damage (p = 0.002). The correlation between the anion gap and serum formate on admission was significant (R (2) = 0.28; p < 0.05). The anion gap well correlated with the variables characterizing the sever
Czech name
—
Czech description
—
Classification
Type
Jx - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FE - Other fields of internal medicine
OECD FORD branch
—
Result continuities
Project
GAP208/12/1645: Aspects of hazardous metals transfer across biomembranes
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Monatshefte für Chemie
ISSN
0026-9247
e-ISSN
—
Volume of the periodical
146
Issue of the periodical within the volume
5
Country of publishing house
AT - AUSTRIA
Number of pages
8
Pages from-to
787-794
UT code for WoS article
000353219700008
EID of the result in the Scopus database
2-s2.0-84939952847
Basic information
Result type
Jx - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP
FE - Other fields of internal medicine
Year of implementation
2015