Analysis of serum anion gap and osmolal gap in diagnosis and prognosis of acute methanol poisoning: clinical study in 86 patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10295078" target="_blank" >RIV/00216208:11110/15:10295078 - isvavai.cz</a>

Alternative codes found

RIV/61388955:_____/15:00443514 RIV/00064165:_____/15:10295078

Result on the web

<a href="http://dx.doi.org/10.1007/s00706-014-1374-7" target="_blank" >http://dx.doi.org/10.1007/s00706-014-1374-7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00706-014-1374-7" target="_blank" >10.1007/s00706-014-1374-7</a>

Result language

angličtina

Original language name

Analysis of serum anion gap and osmolal gap in diagnosis and prognosis of acute methanol poisoning: clinical study in 86 patients

Original language description

We performed a retrospective study in 86 patients from the Czech methanol outbreak in 2012 to determine the role of anion and osmolal gaps in diagnosis and prognosis of methanol poisoning. Methanol and ethanol were measured by a gas chromatographic method with flame ionization detection. Formate was measured enzymatically. Osmolality was measured by freezing point depression method. From 86 patients, 15 died, 47 survived without, and 24 survived with visual/CNS sequelae. There was a statistically significant correlation between the osmolal gap and serum methanol concentrations (R (2) = 0.704; p < 0.001); however, the sensitivity was low for the detection of serum methanol under 20 mmol dm(-3). The survivors without sequelae had lower osmolal gap than those who survived with visual/CNS damage (p = 0.002). The correlation between the anion gap and serum formate on admission was significant (R (2) = 0.28; p < 0.05). The anion gap well correlated with the variables characterizing the sever

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FE - Other fields of internal medicine

OECD FORD branch

—

Project

<a href="/en/project/GAP208%2F12%2F1645" target="_blank" >GAP208/12/1645: Aspects of hazardous metals transfer across biomembranes</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Monatshefte für Chemie

ISSN

0026-9247

e-ISSN

—

Volume of the periodical

146

Issue of the periodical within the volume

5

Country of publishing house

AT - AUSTRIA

Number of pages

8

Pages from-to

787-794

UT code for WoS article

000353219700008

EID of the result in the Scopus database

2-s2.0-84939952847