A Rare Truncating BRCA2 Variant and Genetic Susceptibility to Upper Aerodigestive Tract Cancer

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10295594" target="_blank" >RIV/00216208:11110/15:10295594 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15110/15:33154946

Result on the web

<a href="http://dx.doi.org/10.1093/jnci/djv037" target="_blank" >http://dx.doi.org/10.1093/jnci/djv037</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/jnci/djv037" target="_blank" >10.1093/jnci/djv037</a>

Result language

angličtina

Original language name

A Rare Truncating BRCA2 Variant and Genetic Susceptibility to Upper Aerodigestive Tract Cancer

Original language description

Deleterious BRCA2 genetic variants markedly increase risk of developing breast cancer. A rare truncating BRCA2 genetic variant, rs11571833 (K3326X), has been associated with a 2.5-fold risk of lung squamous cell carcinoma but only a modest 26% increase in breast cancer risk. We analyzed the association between BRCA2 SNP rs11571833 and upper aerodigestive tract (UADT) cancer risk with multivariable unconditional logistic regression adjusted by sex and combinations of study and country for 5942 UADT squamous cell carcinoma case patients and 8086 control patients from nine different studies. All statistical tests were two-sided. rs11571833 was associated with UADT cancers (odds ratio = 2.53, 95% confidence interval = 1.89 to 3.38, P = 3x10(-10)) and was present in European, Latin American, and Indian populations but extremely rare in Japanese populations. The association appeared more apparent in smokers (current or former) compared with never smokers (P-het = .026). A robust association

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of the National Cancer Institute

ISSN

0027-8874

e-ISSN

—

Volume of the periodical

107

Issue of the periodical within the volume

5

Country of publishing house

US - UNITED STATES

Number of pages

4

Pages from-to

1-4

UT code for WoS article

000355088600010

EID of the result in the Scopus database

2-s2.0-84925942447