A 40-bp VNTR polymorphism in the 3 '-untranslated region of DAT1/SLC6A3 is associated with ADHD but not with alcoholism

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10295617" target="_blank" >RIV/00216208:11110/15:10295617 - isvavai.cz</a>

Alternative codes found

RIV/67985904:_____/15:00445121 RIV/00216224:14310/15:00087478 RIV/00064165:_____/15:10295617

Result on the web

<a href="http://dx.doi.org/10.1186/s12993-015-0066-8" target="_blank" >http://dx.doi.org/10.1186/s12993-015-0066-8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12993-015-0066-8" target="_blank" >10.1186/s12993-015-0066-8</a>

Result language

angličtina

Original language name

A 40-bp VNTR polymorphism in the 3 '-untranslated region of DAT1/SLC6A3 is associated with ADHD but not with alcoholism

Original language description

Background: ADHD and alcoholism are psychiatric diseases with pathophysiology related to dopamine system. DAT1 belongs to the SLC6 family of transporters and is involved in the regulation of extracellular dopamine levels. A 40 bp variable number tandem repeat (VNTR) polymorphism in the 3'-untranslated region of DAT1/SLC6A3 gene was previously reported to be associated with various phenotypes involving disturbed regulation of dopaminergic neurotransmission. Methods: A total of 1312 subjects were includedand genotyped for 40 bp VNTR polymorphism of DAT1/SLC6A3 gene in this study (441 alcoholics, 400 non-alcoholic controls, 218 ADHD children and 253 non ADHD children). Using miRBase software, we have performed a computer analysis of VNTR part of DAT1 gene for presence of miRNA binding sites. Results: We have found significant relationships between ADHD and the 40 bp VNTR polymorphisms of DAT1/SLC6A3 gene (P < 0.01). The 9/9 genotype appeared to reduce the risk of ADHD about 0.4-fold (p <

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FL - Psychiatry, sexology

OECD FORD branch

—

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Behavioral and Brain Functions

ISSN

1744-9081

e-ISSN

—

Volume of the periodical

11

Issue of the periodical within the volume

June

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

—

UT code for WoS article

000356474900001

EID of the result in the Scopus database

2-s2.0-84935889527