A case-control study of the relationship between 13 candidate genes and ADHD

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F06%3A00017436" target="_blank" >RIV/00216224:14310/06:00017436 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
A case-control study of the relationship between 13 candidate genes and ADHD
Original language description
Attention deficit hyperactivity disorder (ADHD) is a multifactorial disorder with significant genetic contribution. Dopamine genes have been the initial candidates based on the site of the action of the psychostimulant drugs. The other genes from neurotransmitter and immune system are in focus too. We have investigated whether there is an association between ADHD and polymorphisms of 13 candidate genes: DAT1, DRD2, COMT, MAOB, ACE, ANG, CCR5, BDNF, MU, IL-2, IL-6, TNF-alpha, and M235T. The aim of our case-control study was to determine whether the ADHD boys (118) have different genotype and alelic frequencies of examined polymorphisms of the above mentioned genes compared to controls (153). No significant differences were found between groups of boys in allelic and genotype frequencies of COMT, MAOB, ACE, ANG, CCR5, BDNF, MU, IL-2, IL-6, TNF-alpha and M235T genes (p < 0.05). For DAT1, the statistical analysis using Fisher exact test did not confirme the association of the previously
Czech name
Asociační studie vztahu mezi 13 kandidátními geny a ADHD
Czech description
Při zkoumání vztahu mezi ADHD a 13-ti polymorfizmy kandidátních genů jsme objevili vztah mezi genem pro DAT1, DRD2 a ADHD.

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
<a href="/en/project/NR8137" target="_blank" >NR8137: Molecular causes of dispositions to alcoholism.</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2006
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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