Conversion from clinically isolated syndrome to multiple sclerosis: A large multicentre study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10295997" target="_blank" >RIV/00216208:11110/15:10295997 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/15:10295997
Result on the web
<a href="http://dx.doi.org/10.1177/1352458514568827" target="_blank" >http://dx.doi.org/10.1177/1352458514568827</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1177/1352458514568827" target="_blank" >10.1177/1352458514568827</a>
Alternative languages
Result language
angličtina
Original language name
Conversion from clinically isolated syndrome to multiple sclerosis: A large multicentre study
Original language description
Background and objective: We explored which clinical and biochemical variables predict conversion from clinically isolated syndrome (CIS) to clinically definite multiple sclerosis (CDMS) in a large international cohort. Methods: Thirty-three centres provided serum samples from 1047 CIS cases with at least two years' follow-up. Age, sex, clinical presentation, T2-hyperintense lesions, cerebrospinal fluid (CSF) oligoclonal bands (OCBs), CSF IgG index, CSF cell count, serum 25-hydroxyvitamin D3 (25-OH-D),cotinine and IgG titres against Epstein-Barr nuclear antigen 1 (EBNA-1) and cytomegalovirus were tested for association with risk of CDMS. Results: At median follow-up of 4.31 years, 623 CIS cases converted to CDMS. Predictors of conversion in multivariable analyses were OCB (HR = 2.18, 95% CI = 1.71-2.77, p < 0.001), number of T2 lesions (two to nine lesions vs 0/1 lesions: HR = 1.97, 95% CI = 1.52-2.55, p < 0.001; >9 lesions vs 0/1 lesions: HR = 2.74, 95% CI = 2.04-3.68, p < 0.001) and
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
—
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Multiple Sclerosis
ISSN
1352-4585
e-ISSN
—
Volume of the periodical
21
Issue of the periodical within the volume
8
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
1013-1024
UT code for WoS article
000357738700009
EID of the result in the Scopus database
2-s2.0-84929479105