Interleukin 35 Synovial Fluid Levels Are Associated with Disease Activity of Rheumatoid Arthritis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10296543" target="_blank" >RIV/00216208:11110/15:10296543 - isvavai.cz</a>
Alternative codes found
RIV/00023728:_____/15:#0005041
Result on the web
<a href="http://dx.doi.org/10.1371/journal.pone.0132674" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0132674</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pone.0132674" target="_blank" >10.1371/journal.pone.0132674</a>
Alternative languages
Result language
angličtina
Original language name
Interleukin 35 Synovial Fluid Levels Are Associated with Disease Activity of Rheumatoid Arthritis
Original language description
Objectives To study the association of systemic and local interleukin-35 (IL-35) levels in rheumatoid arthritis. Methods 37 patients with treatment naive early RA, 49 with established RA and 29 control patients with osteoarthritis (OA) were studied. Serum and paired synovial fluid samples were analysed for IL-35. Disease activity of RA patients was assessed according to the 28-Joint Count Disease Activity Score (DAS28). Results The levels of serum IL-35 were significantly higher in patients with treatment naive early RA compared to those with established disease and control OA subjects. In addition, serum levels of IL-35 significantly decreased 12 weeks after initiation of glucocorticoids and conventional synthetic disease modifying antirheumatic drugsin patients with treatment naive early RA. Synovial fluid IL-35 levels were significantly higher in RA compared to OA patients, were significantly elevated compared to serum counterparts and correlated with synovial fluid leukocyte count
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FN - Epidemiology, infection diseases and clinical immunology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT12440" target="_blank" >NT12440: IL-35: a novel cytokine in systemic rheumatic diseases</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLoS ONE
ISSN
1932-6203
e-ISSN
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Volume of the periodical
10
Issue of the periodical within the volume
7
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
1-8
UT code for WoS article
000358621000011
EID of the result in the Scopus database
2-s2.0-84941790864