The level of fatty acid-binding protein 4, a novel adipokine, is increased in rheumatoid arthritis and correlates with serum cholesterol levels

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10190437" target="_blank" >RIV/00216208:11110/13:10190437 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/13:43907676 RIV/00064165:_____/13:10190437 RIV/00023728:_____/13:#0004116
Result on the web
<a href="http://dx.doi.org/10.1016/j.cyto.2013.05.001" target="_blank" >http://dx.doi.org/10.1016/j.cyto.2013.05.001</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.cyto.2013.05.001" target="_blank" >10.1016/j.cyto.2013.05.001</a>

Result language
angličtina
Original language name
The level of fatty acid-binding protein 4, a novel adipokine, is increased in rheumatoid arthritis and correlates with serum cholesterol levels
Original language description
Objective: To assess the expression of the novel adipokine Fatty Acid Binding Protein-4 (FABP4) in synovial tissues, serum and the synovial fluid of patients with rheumatoid arthritis (RA) and osteoarthritis (OA) and to study the relationships among FABP4, disease activity and metabolic status. Methods: FABP4 levels were measured in the serum and synovial fluid of 40 patients with RA and 40 control patients with OA. The disease activity score (DAS28), C-reactive protein (CRP) levels and serum lipids were assessed in patients with RA. Immunohistochemical analysis and confocal microscopy were used to study the expression and cell-specific distribution of FABP4 in synovial tissues. Results: The age, sex and body mass index (BMI) adjusted levels of FABP4 were significantly higher in the serum (p = 0.001) and synovial fluid (p = 0.005) of patients with RA when compared to OA patients. FABP4 levels were higher in females than in males and correlated positively with body mass index (BMI) in p
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Project
<a href="/en/project/NS10620" target="_blank" >NS10620: Contribution of adipocyte/macrophage fatty acid-binding protein (FABP)-4 to the pathogenesis of rheumatoid arthritis and osteoarthritis</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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