Circulating 25-Hydroxyvitamin D-3 and Survival after Diagnosis with Kidney Cancer
Result description
Prospective cohort studies have provided some evidence that circulating vitamin D is associated with risk of, and survival from, renal cell carcinoma (RCC), but it is unclear whether concentrations of vitamin D at the time of diagnosis of RCC are associated with prognosis. We conducted a case-cohort study of 630 RCC cases, including 203 deaths, from a multicenter case-control study in Eastern Europe. Vitamin D was assessed as 25-hydroxyvitamin D-3 [25(OH)D-3], and we used weighted Cox models to estimatehazard ratios (HR) and 95% confidence intervals (CI) by categories of season-adjusted 25(OH)D-3. Higher concentrations of 25(OH)D-3 were associated with lower risk of death after adjusting for stage, age, sex, and country (HR highest vs. lowest category0.57; 95% CI, 0.34-0.97). The inverse associations of 25(OH)D-3 with death were most notable among those who died from non-RCC causes and those diagnosed with early-stage disease. In summary, 25(OH)D-3 concentration at diagnosis of RCC w
Keywords
menwomenplasmacommunityriskgeneral-populationcase-cohort designall-cause mortality
The result's identifiers
Result code in IS VaVaI
Alternative codes found
RIV/61989592:15110/15:33154945
Result on the web
DOI - Digital Object Identifier
Alternative languages
Result language
angličtina
Original language name
Circulating 25-Hydroxyvitamin D-3 and Survival after Diagnosis with Kidney Cancer
Original language description
Prospective cohort studies have provided some evidence that circulating vitamin D is associated with risk of, and survival from, renal cell carcinoma (RCC), but it is unclear whether concentrations of vitamin D at the time of diagnosis of RCC are associated with prognosis. We conducted a case-cohort study of 630 RCC cases, including 203 deaths, from a multicenter case-control study in Eastern Europe. Vitamin D was assessed as 25-hydroxyvitamin D-3 [25(OH)D-3], and we used weighted Cox models to estimatehazard ratios (HR) and 95% confidence intervals (CI) by categories of season-adjusted 25(OH)D-3. Higher concentrations of 25(OH)D-3 were associated with lower risk of death after adjusting for stage, age, sex, and country (HR highest vs. lowest category0.57; 95% CI, 0.34-0.97). The inverse associations of 25(OH)D-3 with death were most notable among those who died from non-RCC causes and those diagnosed with early-stage disease. In summary, 25(OH)D-3 concentration at diagnosis of RCC w
Czech name
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Czech description
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Classification
Type
Jx - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cancer Epidemiology Biomarkers and Prevention
ISSN
1055-9965
e-ISSN
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Volume of the periodical
24
Issue of the periodical within the volume
8
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
1277-1281
UT code for WoS article
000359320500018
EID of the result in the Scopus database
2-s2.0-84941775696
Basic information
Result type
Jx - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP
FD - Oncology and haematology
Year of implementation
2015