Prediction of Adrenocortical Insufficiency After Pituitary Adenoma Surgery Using Postoperative Basal Cortisol Levels

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10297774" target="_blank" >RIV/00216208:11110/15:10297774 - isvavai.cz</a>

Alternative codes found

RIV/61383082:_____/15:#0000359 RIV/00023761:_____/15:#0000558 RIV/00064165:_____/15:10297774

Result on the web

<a href="http://www.biomed.cas.cz/physiolres/pdf/64/64_531.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/64/64_531.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Prediction of Adrenocortical Insufficiency After Pituitary Adenoma Surgery Using Postoperative Basal Cortisol Levels

Original language description

Our aim was to analyze the correlation of early postoperative cortisol levels in patients after transsphenoidal pituitary adenoma surgery compared to the standard dose ACTH test and Insulin tolerance test (ITT) several months later. We retrospectively reviewed data from 94 patients operated for pituitary adenoma in years 2009-2012. The comparison of day 7 (median) postoperative basal cortisol levels and 3.6 months (median) after pituitary adenoma surgery stimulation test - standard dose 250 mu g 1-24ACTH test in 83 patients or ITT in 11 patients were performed. All 16 patients with early postoperative cortisol levels >500 nmol/l proved a sufficient response in the stimulation tests. At basal cortisol levels of 370-500 nmol/l the sufficient response wasfound in 96 % (27/28) of patients. In the postoperative basal cortisol levels 200-370 nmol/l we found a preserved corticotroph axis later on in 88 % (28/32) of cases. Patients with basal cortisol levels 100-200 nmol/l had a maintained co

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FB - Endocrinology, diabetology, metabolism, nutrition

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

64

Issue of the periodical within the volume

4

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

6

Pages from-to

531-536

UT code for WoS article

000360636500011

EID of the result in the Scopus database

2-s2.0-84941061423