Response of Cortisol Metabolites in the Insulin Tolerance Test and Synacthen Tests

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10313572" target="_blank" >RIV/00216208:11110/15:10313572 - isvavai.cz</a>

Alternative codes found

RIV/00023761:_____/15:#0000571 RIV/00064165:_____/15:10313572

Result on the web

<a href="http://www.biomed.cas.cz/physiolres/pdf/64/64_S237.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/64/64_S237.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Response of Cortisol Metabolites in the Insulin Tolerance Test and Synacthen Tests

Original language description

Determination of response of cortisol and its metabolites to different stimuli may be important for adrenal gland disorders. To date, only one metabolite, cortisone, has been followed in stimulation tests of the adrenal gland. We aimed to describe a response of cortisol metabolites to the standard short Synacthen test (HDST), insulin tolerance test (ITT), low dose Synacthen test (LDST) and medium dose Synacthen test (MDST). Sixty healthy subjects were investigated: 30 men and 30 women. Plasma for measurements of cortisol and its metabolites was obtained before and 30th and 60th min after Synacthen and insulin administration. The cut-off 500 nmol/l of cortisol was reached after stimulation in all of tests, the maximal stimulation level was reached in 60th min in all of the tests except for LDST. The response of cortisol and its metabolites at 30th and 60th min strongly correlated in all of the tests except for LDST. Cortisol and its metabolites increased after stimulation; in contrast,

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FB - Endocrinology, diabetology, metabolism, nutrition

OECD FORD branch

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Project

<a href="/en/project/NT11277" target="_blank" >NT11277: Standardization of dynamic tests of hypocorticalism</a><br>

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

64

Issue of the periodical within the volume

Supplement 2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

10

Pages from-to

"S237"-"S246"

UT code for WoS article

000365011800018

EID of the result in the Scopus database

2-s2.0-84952664094