Intraindividual changes of dipeptidyl peptidase-IV in peripheral blood of patients with rheumatoid arthritis are associated with the disease activity

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10297905" target="_blank" >RIV/00216208:11110/15:10297905 - isvavai.cz</a>
Alternative codes found
RIV/00023728:_____/15:#0005043
Result on the web
<a href="http://dx.doi.org/10.1186/s12891-015-0707-y" target="_blank" >http://dx.doi.org/10.1186/s12891-015-0707-y</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s12891-015-0707-y" target="_blank" >10.1186/s12891-015-0707-y</a>

Result language
angličtina
Original language name
Intraindividual changes of dipeptidyl peptidase-IV in peripheral blood of patients with rheumatoid arthritis are associated with the disease activity
Original language description
Background: Dipeptidyl peptidase-IV (DPP-IV) is suggested to contribute to the pathogenesis of several autoimmune diseases. The aim of this study was to evaluate the association of DPP-IV presence in blood plasma and mononuclear cells with the disease activity in rheumatoid arthritis (RA). Methods: Patients with active RA (n = 27) were examined at the study enrolment and a follow-up examination was performed after the regression of the joint effusions and at least 6 months after the first investigation.The control group comprised patients with a noninflammatory joint disease, i.e. osteoarthritis (OA; n = 15). The DPP-IV-like enzymatic activity was measured by a kinetic fluorimetric method, the concentration of DPP-IV in the blood plasma was determinedusing ELISA and the expression of DPP-IV in leukocytes was assayed by flow cytometry. Conclusions: The association between RA activity and the changes in blood plasma and blood mononuclear cell DPP-IV in individual patients supports the
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FE - Other fields of internal medicine
OECD FORD branch
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Project
<a href="/en/project/NR9273" target="_blank" >NR9273: Local and systemic pathogenetic role of "DASH system" molecules in rheumatoid arthritis</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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