Identification and quantification of acidosis inducing metabolites in cases of alcohols intoxication by GC-MS for emergency toxicology

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10297938" target="_blank" >RIV/00216208:11110/15:10297938 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/15:10297938 RIV/00064165:_____/15:10297938
Result on the web
<a href="http://dx.doi.org/10.1016/j.jpba.2015.04.039" target="_blank" >http://dx.doi.org/10.1016/j.jpba.2015.04.039</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jpba.2015.04.039" target="_blank" >10.1016/j.jpba.2015.04.039</a>

Result language
angličtina
Original language name
Identification and quantification of acidosis inducing metabolites in cases of alcohols intoxication by GC-MS for emergency toxicology
Original language description
A simple, cost effective, and fast gas chromatography method with mass spectrometry detection (GC-MS) for simultaneous measurement of formic acid, glycolic acid, methoxyacetic acid, ethoxyacetic acid and 2-hydroxyethoxyacetic acid in serum and urine wasdeveloped and validated. This multi-analyte method is highly suitable for clinical and emergency toxicology laboratory diagnostic, allowing identification and quantification of five most common acidosis inducing organic acids present in cases of alcoholintoxication. Furthermore, when patients are admitted to emergency unit at late stage of toxic alcohol intoxication, the concentration of parent compound may be already low or not detectable. This new method employs a relatively less used class of derivatization agents - alkyl chloroformates, allowing the efficient and rapid derivatization of carboxylic acids within seconds. The entire sample preparation procedure is completed within 5 min. The optimal conditions of derivatization proced
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
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Project
<a href="/en/project/GA13-01440S" target="_blank" >GA13-01440S: Chiral supramolecular polymers based on derivatized cyclodextrins as a new environment for capillary separation techniques</a><br>
Continuities
O - Projekt operacniho programu

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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