Fast determination of ethylene glycol, 1,2-propylene glycol and glycolic acid in blood serum and urine for emergency and clinical toxicology by GC-FID

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10281798" target="_blank" >RIV/00216208:11110/14:10281798 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11310/14:10281798 RIV/00064165:_____/14:10281798

Result on the web

<a href="http://dx.doi.org/10.1016/j.talanta.2014.07.020" target="_blank" >http://dx.doi.org/10.1016/j.talanta.2014.07.020</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.talanta.2014.07.020" target="_blank" >10.1016/j.talanta.2014.07.020</a>

Result language

angličtina

Original language name

Fast determination of ethylene glycol, 1,2-propylene glycol and glycolic acid in blood serum and urine for emergency and clinical toxicology by GC-FID

Original language description

A simple, cost effective, and fast gas chromatography method with flame ionization detection (GC-FID) for simultaneous measurement of ethylene glycol, 1,2-propylene glycol and glycolic acid was developed and validated for clinical toxicology purposes. This new method employs a relatively less used class of derivatization agents - alkyl chloroformates, allowing the efficient and rapid derivatization of carboxylic acids within seconds while glycols are simultaneously derivatized by phenylboronic acid. Theentire sample preparation procedure is completed within 10 min. To avoid possible interference from naturally occurring endogenous acids and quantitation errors 3-(4-chlorophenyl) propionic acid was chosen as an internal standard. The significant parameters of the derivatization have been found using chemometric procedures and these parameters were optimized using the face-centered central composite design. The calibration dependence of the method was proved to be quadratic in the range

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CB - Analytical chemistry, separation

OECD FORD branch

—

Project

—

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Talanta

ISSN

0039-9140

e-ISSN

—

Volume of the periodical

130

Issue of the periodical within the volume

December

Country of publishing house

GB - UNITED KINGDOM

Number of pages

5

Pages from-to

470-474

UT code for WoS article

000341897800066

EID of the result in the Scopus database

—