Simultaneous Determination of Methanol, Ethanol and Formic Acid in Serum and Urine by Headspace GC-FID

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10313288" target="_blank" >RIV/00216208:11110/15:10313288 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/15:10313288 RIV/00064165:_____/15:10313288
Result on the web
<a href="http://dx.doi.org/10.1093/jat/bkv075" target="_blank" >http://dx.doi.org/10.1093/jat/bkv075</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/jat/bkv075" target="_blank" >10.1093/jat/bkv075</a>

Result language
angličtina
Original language name
Simultaneous Determination of Methanol, Ethanol and Formic Acid in Serum and Urine by Headspace GC-FID
Original language description
A simple, cost-effective headspace gas chromatography (GC) method coupled with GC with flame ionization detection for simultaneous determination of methanol, ethanol and formic acid was developed and validated for clinical and toxicological purposes. Formic acid was derivatized with an excess of isopropanol under acidic conditions to its volatile isopropyl ester while methanol and ethanol remained unchanged. The entire sample preparation procedure is complete within 6 min. The design of the experiment (the face-centered central composite design) was used for finding the optimal conditions for derivatization, headspace sampling and chromatographic separation. The calibration dependences of the method were quadratic in the range from 50 to 5,000 mg/L, with adequate accuracy (89.0-114.4%) and precision (<12%) in the serum. The new method was successfully used for determination of selected analytes in serum samples of intoxicated patients from among those affected by massive methanol poiso
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
—

Project
<a href="/en/project/GA13-01440S" target="_blank" >GA13-01440S: Chiral supramolecular polymers based on derivatized cyclodextrins as a new environment for capillary separation techniques</a><br>
Continuities
O - Projekt operacniho programu

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)