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Simultaneous and cost-effective determination of ethylene glycol and glycolic acid in human serum and urine for emergency toxicology by GC-MS

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10293513" target="_blank" >RIV/00216208:11310/15:10293513 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11110/15:10293513 RIV/00064165:_____/15:10293513

  • Result on the web

    <a href="http://dx.doi.org/10.1016/j.clinbiochem.2014.12.002" target="_blank" >http://dx.doi.org/10.1016/j.clinbiochem.2014.12.002</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.clinbiochem.2014.12.002" target="_blank" >10.1016/j.clinbiochem.2014.12.002</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Simultaneous and cost-effective determination of ethylene glycol and glycolic acid in human serum and urine for emergency toxicology by GC-MS

  • Original language description

    Objectives: A simple, cost-effective, and fast gas chromatography method with mass spectrometry detection (GC-MS) for simultaneous measurement of ethylene glycol, 1,2-propylene glycol and glycolic acid was developed and validated for clinical toxicologypurposes. Design and methods: Successful derivatization of glycolic acid with isobutyl chloroformate was achieved directly in serum/urine while glycols are simultaneously derivatized by phenylboronic acid. The entire sample preparation procedure is completed within 10 min. Results: The assay was proved to be quadratic in the range of 50 to 5000 mg L-1 with adequate accuracy (96.3-105.8%) and precision (CV {= 8.9%). Conclusion: The method was successfully applied to quantify the selected compounds in serum of patients from emergency units and the results correlated well with parallel GC-FID measurements (R-2 0.9933 for ethylene glycol and 0.9943 for glycolic acid). (C) 2014 The Canadian Society of Clinical Chemists. Published by Elsevier

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CB - Analytical chemistry, separation

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Clinical Biochemistry

  • ISSN

    0009-9120

  • e-ISSN

  • Volume of the periodical

    48

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    CA - CANADA

  • Number of pages

    3

  • Pages from-to

    189-191

  • UT code for WoS article

    000348703300019

  • EID of the result in the Scopus database

    2-s2.0-84919499914