Protective associations of HDL with blood-brain barrier injury in multiple sclerosis patients

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10301839" target="_blank" >RIV/00216208:11110/15:10301839 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/15:10301839
Result on the web
<a href="http://dx.doi.org/10.1194/jlr.M060970" target="_blank" >http://dx.doi.org/10.1194/jlr.M060970</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1194/jlr.M060970" target="_blank" >10.1194/jlr.M060970</a>

Result language
angličtina
Original language name
Protective associations of HDL with blood-brain barrier injury in multiple sclerosis patients
Original language description
The purpose of this work was to investigate the associations of serum cholesterol and apolipoproteins with measures of blood-brain barrier (BBB) permeability and CNS inflammation following the first clinical demyelinating event. This study included 154 patients [67% female; age, 29.5 +/- 8.2 years (mean +/- SD)] enrolled in a multi-center study of interferon 1-a treatment following the first demyelinating event. Blood and cerebrospinal fluid (CSF) were obtained at screening prior to treatment. A comprehensive serum lipid profile and multiple surrogate markers of BBB breakdown and CNS immune activity were obtained. Higher levels of serum HDL cholesterol (HDL-C) and ApoA-I were associated with lower CSF total protein level, CSF albumin level, albumin quotient, and CSF IgG level (all P 0.001 for HDL-C and all P < 0.01 for ApoA-I). HDL-C was also associated with CSF CD80+ (P < 0.001) and with CSF CD80+CD19+ (P = 0.007) cell frequencies. Higher serum HDL is associated with lower levels of B
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
—

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)