The impact of standard chemotherapy on miRNA signature in plasma in AML patients

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10312476" target="_blank" >RIV/00216208:11110/15:10312476 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11140/15:10312476 RIV/00669806:_____/15:10312476 RIV/00064165:_____/15:10312476
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0145212615303623" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0145212615303623</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.leukres.2015.08.009" target="_blank" >10.1016/j.leukres.2015.08.009</a>

Result language
angličtina
Original language name
The impact of standard chemotherapy on miRNA signature in plasma in AML patients
Original language description
tAim: In our pilot study, we used plasma samples as liquid biopsy to search for miRNA signatures in patientswith acute myeloid leukemia (AML) at diagnosis and in remission achieved after standard chemotherapybefore planned transplantation.Material and methods: We examined 10 plasma samples from healthy volunteers and 8 paired samplesfrom patients with AML at diagnosis and in remission using TaqMan MicroRNA Arrays. The results werevalidated using single-target qPCR reactions run in triplicates.Results: We selected 6 miRNAs with expressions significantly sensitive to therapy: miR-199b-5p, miR-301b, miR-326, miR-361-5p, miR-625 and miR-655. All selected miRNAs were not or very weaklyexpressed in healthy individuals. They were abundant in plasma in patients at diagnosis but their levelsdecreased after chemotherapy.Conclusion: We detected a therapy sensitive miRNA signature in plasma of patients with AML.
Czech name
—
Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
—

Project
<a href="/en/project/FR-TI1%2F328" target="_blank" >FR-TI1/328: *R and D of certified technologie isolation of DNA from histopatologic material</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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