Hepatic triacylglycerol composition in experimental model of non-alcoholic steatohepatitis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10312757" target="_blank" >RIV/00216208:11110/15:10312757 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/15:10312757
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Hepatic triacylglycerol composition in experimental model of non-alcoholic steatohepatitis
Original language description
Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) probably represent the most common chronic liver diseases in western countries with a substantial risk of liver cirrhosis and high cardiovascular morbidity and mortality.The pathogenic mechanism involved in the development of fatty liver remains unclear. It is known that severity of steatosis is well correlated with progression to NASH in humans, and several recent reports gave suggested that accumulation of lipids in the liver, and especially disturbances in the composition of hepatic fatty acids, might play a causal role in the development of NASH. Intricacies of the molecular and cellular mechanisms responsible for progression from simple steatosis to NASH have not been fully elucidated. Excessive accumulation of lipid substrates in the liver has serious adverse effects on cell functions and especially saturated free fatty acids are directly hepatotoxic, perhaps by mediating an endoplasmic reticulum
Czech name
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Czech description
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Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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