Albumin administration prevents neurological damage and death in a mouse model of severe neonatal hyperbilirubinemia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10312771" target="_blank" >RIV/00216208:11110/15:10312771 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/15:10312771

Result on the web

<a href="http://dx.doi.org/10.1038/srep16203" target="_blank" >http://dx.doi.org/10.1038/srep16203</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/srep16203" target="_blank" >10.1038/srep16203</a>

Result language

angličtina

Original language name

Albumin administration prevents neurological damage and death in a mouse model of severe neonatal hyperbilirubinemia

Original language description

Therapies to prevent severe neonatal unconjugated hyperbilirubinemia and kernicterus are phototherapy and, in unresponsive cases, exchange transfusion, which has significant morbidity and mortality risks. Neurotoxicity is caused by the fraction of unconjugated bilirubin not bound to albumin (free bilirubin, Bf). Human serum albumin (HSA) administration was suggested to increase plasma bilirubin-binding capacity. However, its clinical use is infrequent due to difficulties to address its potential preventive and curative benefits, and to the absence of reliable markers to monitor bilirubin neurotoxicity risk. We used a genetic mouse model of unconjugated hyperbilirubinemia showing severe neurological impairment and neonatal lethality. We treated mutant pups with repeated HSA administration since birth, without phototherapy application. Daily intraperitoneal HSA administration completely rescued neurological damage and lethality, depending on dosage and administration frequency. Albumin i

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Scientific Reports

ISSN

2045-2322

e-ISSN

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Volume of the periodical

5

Issue of the periodical within the volume

November

Country of publishing house

GB - UNITED KINGDOM

Number of pages

13

Pages from-to

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UT code for WoS article

000364236700001

EID of the result in the Scopus database

2-s2.0-84946887783