Albumin administration protects against bilirubin-induced auditory brainstem dysfunction in Gunn rat pups

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10192269" target="_blank" >RIV/00216208:11110/13:10192269 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1111/liv.12219" target="_blank" >http://dx.doi.org/10.1111/liv.12219</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/liv.12219" target="_blank" >10.1111/liv.12219</a>

Result language
angličtina
Original language name
Albumin administration protects against bilirubin-induced auditory brainstem dysfunction in Gunn rat pups
Original language description
Background Free bilirubin (Bf), the unbound fraction of unconjugated bilirubin (UCB), can induce neurotoxicity, including impairment of the auditory system, which can be assessed by brainstem auditory evoked potentials (BAEPs). We hypothesized that albumin might reduce the risk of neurotoxicity by decreasing Bf and its translocation into the brain. AimTo determine the effects of albumin on BAEPs and brain bilirubin content in two Gunn rat pup models of acute hyperbilirubinemia. MethodsWe used Gunn rat pups, which have a deficiency of the bilirubin-conjugating enzyme UGT1A1. We induced haemolysis by injection of phenylhydrazine (phz) into 14-days old pups. Subsequently, pups were treated with either i.p. human serum albumin (HSA; 2.5g/kg; n=8) or saline(control, n=8). We induced acute neurotoxicity by injecting 16-days old pups with sulphadimethoxine (sulpha) and treated them with either HSA (n=9) or saline (control, n=10). To assess bilirubin neurotoxicity, we used the validated BAEP
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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