Bilirubin accumulation and Cyp mRNA expression in selected brain regions of jaundiced Gunn rat pups
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A13165" target="_blank" >RIV/00216208:11110/12:13165 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/12:13165
Result on the web
<a href="http://dx.doi.org/10.1038/pr.2012.23" target="_blank" >http://dx.doi.org/10.1038/pr.2012.23</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Bilirubin accumulation and Cyp mRNA expression in selected brain regions of jaundiced Gunn rat pups
Original language description
INTRODUCTION: Few data exist on regional brain bilirubin content in the neonatal period when acute bilirubin-induced neurologic damage (BIND) may occur, and no information is available on regional brain expression of cytochrome P450 monooxygenases (Cyps)that oxidize bilirubin. METHODS: Bilirubin content was analyzed by high-performance liquid chromatography and Cyp1a1, 1a2, and 2a3 mRNA expression was analyzed by quantitative PCR (qPCR) in cortex (Cx), cerebellum (CII), superior colliculi (SC), and inferior colliculi (IC) of 17-d-old hyperbilirubinemic (jj) Gunn rat pups before and after administration of sulphadimethoxine to acutely displace bilirubin from plasma albumin. RESULTS:There was no difference in bilirubin content among brain regions in untreated rats. After intraperitoneal sulphadimethoxine, bilirubin content peaked at fourfold in Cx and SC at 1h; but at 11- to 13-fold in CII and IC at 24h; returning to control levels at 72h. The Cyp mRNA peaked at 30-70 times control at 1
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pediatric Research
ISSN
0031-3998
e-ISSN
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Volume of the periodical
71
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
653-660
UT code for WoS article
000304296200005
EID of the result in the Scopus database
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