Increasing incidence of immune-mediated necrotizing myopathy: single-centre experience

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10313287" target="_blank" >RIV/00216208:11110/15:10313287 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/15:10313287 RIV/00064203:_____/15:10313287 RIV/00023728:_____/15:#0005040

Result on the web

<a href="http://dx.doi.org/10.1093/rheumatology/kev229" target="_blank" >http://dx.doi.org/10.1093/rheumatology/kev229</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/rheumatology/kev229" target="_blank" >10.1093/rheumatology/kev229</a>

Result language

angličtina

Original language name

Increasing incidence of immune-mediated necrotizing myopathy: single-centre experience

Original language description

Objectives. Immune-mediated necrotizing myopathy (IMNM) is characterized by the predominant presence of necrotic muscle fibres in muscle biopsy and variable response to immunosuppressive treatment. The aims of this study were to analyse the temporal trend of IMNM incidence in our centre over the past 10 years and to explore the role of statins as possible causative agents. Methods. A retrospective evaluation of muscle biopsy results, clinical and laboratory data, including antibody associations of all patients with idiopathic inflammatory myopathy newly diagnosed between 2004 and June 2014, was performed. Available sera were tested for the presence of anti-3-hydroxy-3methylglutaryl coenzyme A reductase (anti-HMGCR) autoantibodies. Results. Of 357 biopsied patients, 233 fulfilled criteria for inflammatory/immune-mediated myopathy, including 27 (11.6%) classified as IMNM. There were no patients with IMNM diagnosed between 2004 and 2007; subsequently, two to three cases of IMNM per year w

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FE - Other fields of internal medicine

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Rheumatology

ISSN

1462-0324

e-ISSN

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Volume of the periodical

54

Issue of the periodical within the volume

11

Country of publishing house

GB - UNITED KINGDOM

Number of pages

5

Pages from-to

2010-2014

UT code for WoS article

000364760700012

EID of the result in the Scopus database

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