Buccal epithelial cells as potential non-invasive materials for the monitoring of mitochondrial disturbances to track Huntington's disease progression : a pilot study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10315942" target="_blank" >RIV/00216208:11110/15:10315942 - isvavai.cz</a>

Alternative codes found

RIV/67985904:_____/15:00452792 RIV/00064165:_____/15:10315942

Result on the web

<a href="http://dx.doi.org/10.14735/amcsnn2012S49" target="_blank" >http://dx.doi.org/10.14735/amcsnn2012S49</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14735/amcsnn2012S49" target="_blank" >10.14735/amcsnn2012S49</a>

Result language

angličtina

Original language name

Buccal epithelial cells as potential non-invasive materials for the monitoring of mitochondrial disturbances to track Huntington's disease progression : a pilot study

Original language description

Introduction: Huntington's disease (HD) is an incurable neurodegenerative disorder that manifests progressive behavioral and motoric changes and cognitive dysfunction. It is caused by CAG expansion in huntingtin gene and has almost full penetrance. The striatum is the most affected tissue in HD, but pathological changes are also detected in the peripheral tissues like blood, skeletal muscle or fibroblasts. Intensive HD research in the last years has revealed an important role of mitochondrial dysfunction in the pathogenesis and progression of the disease, which includes changes in the activity of the respiratory chain complexes, ATP synthesis or increased apoptotic stimuli. Aim and material: We decided to analyse the amount of mitochondrial respiratorychain complex I and IV in the epithelial cells of buccal smear in six HD patients and from an animal disease model, minipigs transgenic for the N-terminal part of human mutated huntingtin (TgHD). Methods: The amount of mitochondrial comp

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Česká a slovenská neurologie a neurochirurgie

ISSN

1210-7859

e-ISSN

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Volume of the periodical

78

Issue of the periodical within the volume

Suppl. 2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

6

Pages from-to

"2S49"-"2S54"

UT code for WoS article

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EID of the result in the Scopus database

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