Mitochondrial/Oxidative Stress Biomarkers in Huntington’s Disease

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F23%3A00577188" target="_blank" >RIV/67985904:_____/23:00577188 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/978-3-031-32815-2_13" target="_blank" >http://dx.doi.org/10.1007/978-3-031-32815-2_13</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-3-031-32815-2_13" target="_blank" >10.1007/978-3-031-32815-2_13</a>

Result language
angličtina
Original language name
Mitochondrial/Oxidative Stress Biomarkers in Huntington’s Disease
Original language description
Huntington’s disease (HD) is a hereditary neurodegeneration caused by a mutation in the HTT gene, leading to mutated huntingtin protein aggregation. This results in a widespread dysregulation of cellular pathways and death of medium spiny neurons of the striatum. Due to the high metabolic demand of brain tissue, mitochondrial dysfunction and resulting oxidative stress are common pathological features contributing to many neurodegenerative diseases, including HD. In this review, we summarize studies that measured fluid biomarkers of oxidative stress in HD patients. At the current state of knowledge, none of the reviewed biomarkers can be used as a reliable measure of HD progression or response to treatment in isolation. However, combining biomarkers covering different aspects of mitochondrial dysfunction and oxidative stress with HD specific biomarkers could be a more promising strategy.
Czech name
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Czech description
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Project
<a href="/en/project/GA22-24983S" target="_blank" >GA22-24983S: Autophagy in pathogenesis of Huntington's disease</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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