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Analysis of mitochondrial network morphology in cultured myoblasts from patients with mitochondrial disorders

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10316503" target="_blank" >RIV/00216208:11110/15:10316503 - isvavai.cz</a>

  • Alternative codes found

    RIV/67985823:_____/15:00449498 RIV/00064165:_____/15:10316503 RIV/00216208:11130/15:10316503 RIV/00064203:_____/15:10316503

  • Result on the web

    <a href="http://dx.doi.org/10.3109/01913123.2015.1054013" target="_blank" >http://dx.doi.org/10.3109/01913123.2015.1054013</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3109/01913123.2015.1054013" target="_blank" >10.3109/01913123.2015.1054013</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Analysis of mitochondrial network morphology in cultured myoblasts from patients with mitochondrial disorders

  • Original language description

    Mitochondrial morphology was studied in cultivated myoblasts obtained from patients with mitochondrial disorders, including CPEO, MELAS and TMEM70 deficiency. Mitochondrial networks and ultrastructure were visualized by fluorescence microscopy and transmission electron microscopy, respectively. A heterogeneous picture of abnormally sized and shaped mitochondria with fragmentation, shortening, and aberrant cristae, lower density of mitochondria and an increased number of "megamitochondria" were found inpatient myoblasts. Morphometric Fiji analyses revealed different mitochondrial network properties in myoblasts from patients and controls. The small number of cultivated myoblasts required for semiautomatic morphometric image analysis makes this tool useful for estimating mitochondrial disturbances in patients with mitochondrial disorders. (C) 2015 Taylor & Francis Group, LLC.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EA - Morphology and cytology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Ultrastructural Pathology

  • ISSN

    0191-3123

  • e-ISSN

  • Volume of the periodical

    39

  • Issue of the periodical within the volume

    5

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    11

  • Pages from-to

    340-350

  • UT code for WoS article

    000369734600007

  • EID of the result in the Scopus database

    2-s2.0-84942504181