Analysis of mitochondrial network morphology in cultured myoblasts from patients with mitochondrial disorders
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10316503" target="_blank" >RIV/00216208:11110/15:10316503 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/15:00449498 RIV/00064165:_____/15:10316503 RIV/00216208:11130/15:10316503 RIV/00064203:_____/15:10316503
Result on the web
<a href="http://dx.doi.org/10.3109/01913123.2015.1054013" target="_blank" >http://dx.doi.org/10.3109/01913123.2015.1054013</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/01913123.2015.1054013" target="_blank" >10.3109/01913123.2015.1054013</a>
Alternative languages
Result language
angličtina
Original language name
Analysis of mitochondrial network morphology in cultured myoblasts from patients with mitochondrial disorders
Original language description
Mitochondrial morphology was studied in cultivated myoblasts obtained from patients with mitochondrial disorders, including CPEO, MELAS and TMEM70 deficiency. Mitochondrial networks and ultrastructure were visualized by fluorescence microscopy and transmission electron microscopy, respectively. A heterogeneous picture of abnormally sized and shaped mitochondria with fragmentation, shortening, and aberrant cristae, lower density of mitochondria and an increased number of "megamitochondria" were found inpatient myoblasts. Morphometric Fiji analyses revealed different mitochondrial network properties in myoblasts from patients and controls. The small number of cultivated myoblasts required for semiautomatic morphometric image analysis makes this tool useful for estimating mitochondrial disturbances in patients with mitochondrial disorders. (C) 2015 Taylor & Francis Group, LLC.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EA - Morphology and cytology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Ultrastructural Pathology
ISSN
0191-3123
e-ISSN
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Volume of the periodical
39
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
340-350
UT code for WoS article
000369734600007
EID of the result in the Scopus database
2-s2.0-84942504181