Systematic versus Endoscopy-driven Treatment with Azathioprine to Prevent Postoperative Ileal Crohn's Disease Recurrence

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10320771" target="_blank" >RIV/00216208:11110/15:10320771 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1093/ecco-jcc/jjv076" target="_blank" >http://dx.doi.org/10.1093/ecco-jcc/jjv076</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/ecco-jcc/jjv076" target="_blank" >10.1093/ecco-jcc/jjv076</a>

Result language

angličtina

Original language name

Systematic versus Endoscopy-driven Treatment with Azathioprine to Prevent Postoperative Ileal Crohn's Disease Recurrence

Original language description

Background and Aims: Prophylactic azathioprine (AZA) is efficacious in preventing postoperative Crohn's disease (CD) recurrence. However, it is unknown whether AZA should be started immediately after surgery. We compared the efficacy of systematic vs endoscopy-driven AZA in preventing CD recurrence at week 102. Methods: This prospective, multicentre trial included CD patients undergoing curative resection with ileocolonic anastomosis and at higher risk of recurrence. Patients were randomized to systematic AZA initiated <= 2 weeks from surgery, or endoscopy-driven AZA in which therapy was only initiated in case of endoscopic recurrence (Rutgeerts' score >= i2) at weeks 26 or 52 following surgery. The primary endpoint was endoscopic remission (i0-i1) atweek 102. Secondary endpoints included complete endoscopic remission (i0) and clinical remission. Results: The study was prematurely stopped due to slow recruitment. Between 2005 and 2011, 63 patients (28 male, median age 36 years) were r

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FE - Other fields of internal medicine

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Crohn's and Colitis

ISSN

1873-9946

e-ISSN

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Volume of the periodical

9

Issue of the periodical within the volume

8

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

8

Pages from-to

617-624

UT code for WoS article

000359316900005

EID of the result in the Scopus database

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