Endoscopic Recurrence 6 Months After Ileocecal Resection in Children With Crohn Disease Treated With Azathioprine
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F17%3A10373789" target="_blank" >RIV/00216208:11130/17:10373789 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/17:10373789
Result on the web
<a href="https://doi.org/10.1097/MPG.0000000000001470" target="_blank" >https://doi.org/10.1097/MPG.0000000000001470</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/MPG.0000000000001470" target="_blank" >10.1097/MPG.0000000000001470</a>
Alternative languages
Result language
angličtina
Original language name
Endoscopic Recurrence 6 Months After Ileocecal Resection in Children With Crohn Disease Treated With Azathioprine
Original language description
Objectives:Intestinal surgery is an important part of Crohn disease (CD) treatment in children. The aim of the present study was to compare the rate of endoscopic recurrence at the sixth month after ileocecal resection (ICR) in children with CD treated with azathioprine between patients who received prior antitumor necrosis factor alpha (anti-TNF-alpha) therapy and those who were not administered this therapy. Moreover, we tried to identify the potential risk factors for disease recurrence and describe the schedule of long-term follow-up after surgery. Methods:We prospectively collected data from pediatric patients with CD, who underwent ICR between October 2011 and June 2015 at our hospital and were treated with azathioprine monotherapy after ICR. We evaluated the endoscopic recurrence (Rutgeerts score) at the sixth month after ICR in all included patients. Results:Among 21 included patients, 13 achieved endoscopic remission (Rutgeerts score<i2) at the sixth month after ICR. No difference was found between patients who received prior anti-TNF-alpha therapy and those who did not. We did not find any clinically relevant factors associated with endoscopic recurrence rate at the sixth month. Conclusions:Prior anti-TNF-alpha therapy does not seem to be a strong risk factor for endoscopic recurrence within 6 months after ICR. Further studies on large sample of patients are needed to identify potential predictors of disease recurrence.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30219 - Gastroenterology and hepatology
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Pediatric Gastroenterology & Nutrition
ISSN
0277-2116
e-ISSN
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Volume of the periodical
65
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
207-211
UT code for WoS article
000406471500015
EID of the result in the Scopus database
2-s2.0-85026322826