The Impact of Anti-Tumor Necrosis Factor Alpha Therapy on Postoperative Complications in Pediatric Crohn's Disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F20%3A00525370" target="_blank" >RIV/61388971:_____/20:00525370 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/20:10410805 RIV/00064203:_____/20:10410805
Result on the web
<a href="https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0039-1697909" target="_blank" >https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0039-1697909</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1055/s-0039-1697909" target="_blank" >10.1055/s-0039-1697909</a>
Alternative languages
Result language
angličtina
Original language name
The Impact of Anti-Tumor Necrosis Factor Alpha Therapy on Postoperative Complications in Pediatric Crohn's Disease
Original language description
Introduction The incidence of Crohn's disease (CD) within the pediatric population is increasing worldwide. Despite a growing number of these patients receiving anti-tumor necrosis factor alpha therapy (anti-TNF-alpha), one-third of them still require surgery. There is limited data as to whether anti-TNF-alpha influences postoperative complications. We evaluated postoperative complications in patients who were or were not exposed to anti-TNF-alpha therapy in our institutional cohort.nnMaterials and Methods A retrospective review of CD patients who underwent abdominal surgery between September 2013 and September 2018 was performed. The patients were divided into two groups based on whether they were treated with anti-TNF-alpha within 90 days before surgery. Thirty-day postoperative complications were assessed using Clavien-Dindo classification (D-C), this examination included surgical site infections (SSIs), stoma complications, intra-abdominal septic complications, non-SSIs, bleeding, ileus, readmission rate, and return to the operating room. Mann-Whitney U -test, Fisher's exact test, and multivariate logistic regression analyses were used for statistical analysis.nnResults Sixty-five patients (41 males) with a median age of 16 years (range: 7-19) at the time of operation were identified. The most common surgery was ileocecal resection in 49 (75%) patients. Forty-three (66.2%) patients were treated with anti-TNF-alpha preoperatively. Seven patients (11%) experienced postoperative complications. There was no statistically significant difference in postoperative complication in patients who did or did not receive anti-TNF-alpha before surgery (D-C minor 2.3% vs. 4.6%, p = 1, D-C major 7% vs. 9.1%, p = 1).nnConclusion The use of anti-TNF-alpha in pediatric CD patients within the 90 days prior to their abdominal surgery was not associated with an increased risk of 30-day postoperative complications.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Pediatric Surgery
ISSN
0939-7248
e-ISSN
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Volume of the periodical
30
Issue of the periodical within the volume
1
Country of publishing house
DE - GERMANY
Number of pages
6
Pages from-to
27-32
UT code for WoS article
000516618200005
EID of the result in the Scopus database
2-s2.0-85081268046