Nabumetone and 6-MNA pharmacokinetics, assessment of intrasubject variability and gender effect
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F16%3A10286463" target="_blank" >RIV/00216208:11110/16:10286463 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/16:10286463
Result on the web
<a href="http://dx.doi.org/10.1097/MJT.0000000000000158" target="_blank" >http://dx.doi.org/10.1097/MJT.0000000000000158</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/MJT.0000000000000158" target="_blank" >10.1097/MJT.0000000000000158</a>
Alternative languages
Result language
angličtina
Original language name
Nabumetone and 6-MNA pharmacokinetics, assessment of intrasubject variability and gender effect
Original language description
In this study we describe pharmacokinetics (PK) of nabumetone, which has been previously studied mainly indirectly using its active metabolite. Since the 6-MNA pharmacokinetics suggests that nabumetone belongs to group of highly variable drugs (HVD), we have also evaluatedits intra- and inter- subject variability.We have developed and validated a rapid and sensitive HPLC-UV analytic method for analysis of both nabumetone and 6-MNA. Results show that nabumetone reaches cmax with an average (+-SD) value of 0.5552 +- 0.2021 mg.l-1 at mean tmax of 8.63 +- 7.05 h, with mean AUClast of 18.069 +- 7.190 h.mg.l-1. There were no statistically significant differences between both sexes in PK of nabumetone, however for 6-MNA the mean +- SD AUClast was higher in men than in women with mean respective values of 721.2342 +- 185.5272 h.mg.l-1 and 545.2733 +- 97.6902 h.mg.l-1(p = 0.013), and clearance was lower in men 0.6536 +- 0.2177 l.h-1 in comparison with women 0.8760 +- 0.1751 l.h-1(p = 0.019).Inter-subject variability of nabumetone and 6-MNA was found to be between 35-45% and 10-30% for all assessed parameters (AUClast, cmax, partial AUCs), respectively. The intra-subject variability was only modest, 15.59% and 6.40 % for AUClast for nabumetone and 6-MNA, respectively. The respective values of intra-subject variability for cmax were 13.66 % and 5.42 %.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
American Journal of Therapeutics
ISSN
1075-2765
e-ISSN
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Volume of the periodical
23
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
"e1498"-"e1503"
UT code for WoS article
000388699800032
EID of the result in the Scopus database
2-s2.0-84912019918