Progress in drug development for Alzheimer's disease: An overview in relation to mitochondria energy metabolism

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F16%3A10326637" target="_blank" >RIV/00216208:11110/16:10326637 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.ejmech.2016.03.084" target="_blank" >http://dx.doi.org/10.1016/j.ejmech.2016.03.084</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ejmech.2016.03.084" target="_blank" >10.1016/j.ejmech.2016.03.084</a>

Result language

angličtina

Original language name

Progress in drug development for Alzheimer's disease: An overview in relation to mitochondria energy metabolism

Original language description

Current possibilities of Alzheimer's disease (AD) treatment are very limited and are based on administration of cholinesterase inhibitors (donepezil, rivastigmine, galantamine) and/or N-methyl-D-aspartate receptor antagonist, memantine. Newly synthesized drugs affect multiple AD pathophysiological pathways and can act as inhibitors of cholinesterases (AChE, BuChE), inhibitors of monoamine oxidases (MAO-A, MAO-B), modulators of mitochondrial permeability transition pores, modulators of amyloidbeta binding alcohol dehydrogenase and antioxidants. Effects of clinically used as well as newly developed AD drugs were studied in relation to energy metabolism and mitochondrial functions, including oxidative phosphorylation, activities of enzymes of citric acid cycle or electron transfer system, mitochondrial membrane potential, calcium homeostasis, production of reactive oxygen species and MAO activity.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

—

Project

<a href="/en/project/NV15-28967A" target="_blank" >NV15-28967A: Modulators of mitochondrial enzymes for treatment of neurodegenerative disorders</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Journal of Medicinal Chemistry

ISSN

0223-5234

e-ISSN

—

Volume of the periodical

121

Issue of the periodical within the volume

October

Country of publishing house

FR - FRANCE

Number of pages

11

Pages from-to

774-784

UT code for WoS article

000382269700063

EID of the result in the Scopus database

2-s2.0-84963657194