Comprehensive serial study of dynamic remodeling of atherosclerotic coronary arteries using IVUS

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F16%3A10327331" target="_blank" >RIV/00216208:11110/16:10327331 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1117/12.2217152" target="_blank" >http://dx.doi.org/10.1117/12.2217152</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1117/12.2217152" target="_blank" >10.1117/12.2217152</a>

Result language

angličtina

Original language name

Comprehensive serial study of dynamic remodeling of atherosclerotic coronary arteries using IVUS

Original language description

We present a semi-automated approach to comprehensively examine coronary remodeling over the entire length of intravascular ultrasound (IVUS) imaged vessels. Serial measurements at baseline and 12-month follow-up are analyzed rather than static data obtained at a single time point. Every IVUS pullback is segmented automatically, and then reviewed and algorithmically refined by an expert using a computer-aided just-enough-interaction approach. Subsequently, pairs of serial IVUS pullbacks are registered automatically using 3D graph optimization approach. Based on plaque volume increases or decreases over time, pullback frames are divided into two groups - progression and regression. It is shown that plaque progression rates are positively correlated with percent stenosis (PS) indices (p << 0.01) while plaque regression rates are negatively correlated with percent stenosis indices (p << 0.01). Moreover, for the progression group, adventitia area increases in direct relation with the baseline percent stenosis (p=0.007) when PS is less than 50%. Significance of such a correlation is not observed when percent stenosis exceeds 50%. Conversely, for the regression group, change of adventitia area is relatively constant for percent stenosis <50%; but decreases in direct relation with baseline stenosis (p << 0.01) when stenosis > 50%. This strongly suggests that lipid lowering treatment may effectively suppress plaque progression and accelerate plaque regression, especially for larger values of percent stenosis, and further accelerate the corresponding adventitia-remodeling process.

Czech name

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Czech description

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Type

D - Article in proceedings

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

—

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging

ISBN

978-1-5106-0023-2

ISSN

0277-786X

e-ISSN

—

Number of pages

6

Pages from-to

—

Publisher name

SPIE

Place of publication

San Diego

Event location

San Diego

Event date

Mar 1, 2016

Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

000378223800030