Near-infrared spectroscopy combined with intravascular ultrasound in carotid arteries

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F16%3A10323761" target="_blank" >RIV/00064203:_____/16:10323761 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/16:10323761

Result on the web

<a href="http://dx.doi.org/10.1007/s10554-015-0687-x" target="_blank" >http://dx.doi.org/10.1007/s10554-015-0687-x</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10554-015-0687-x" target="_blank" >10.1007/s10554-015-0687-x</a>

Result language

angličtina

Original language name

Near-infrared spectroscopy combined with intravascular ultrasound in carotid arteries

Original language description

Limited insights into the pathophysiology of the atherosclerotic carotid stenosis are available in vivo. We conducted a prospective study to assess safety and feasibility of intravascular ultrasound (IVUS) combined with near-infrared spectroscopy (NIRS) in carotid arteries. In addition, we described the size and the distribution of lipid rich plaques in significant atherosclerotic carotid stenoses. In a prospective single centre study 45 consecutive patients (mean age 66 +/- A 8 years) with symptomatic (a parts per thousand yen50 %) or asymptomatic (a parts per thousand yen70 %) stenosis of internal carotid artery (ICA) amendable to carotid stenting were enrolled. A 40 mm long NIRS-IVUS pullback through the stenosis was performed. IVUS and NIRS data were analyzed to assess minimal luminal area (MLA), plaque burden (PB), remodeling index (RI), calcifications, lipid core burden index (LCBI), maximal LCBI in any 4 mm segment of the artery (LCBImx) and LCBI in the 4 mm segment at the site of minimal luminal area (LCBImxMLA). NIRS-IVUS pullbacks were safely performed without overt clinical events. LCBImx was significantly higher than LCBImxMLA (369.1 +/- A 221.1 vs. 215.7 +/- A 2589; p = 0.004). Conversely, PB was significantly larger at the site of MLA (87.4 +/- A 4.8 % vs. 58.3 +/- A 18.2 %; p < 0001). Distance of the NIRS-IVUS frame with the highest LCBI from the site of MLA was 6.5 +/- A 7.7 mm. Eighty percent of frames with maximal LCBI were localized within 10 mm from the site of MLA and 67 % proximally to or at the site of MLA. This study suggested safety and feasibility of the NIRS-IVUS imaging of the carotid stenosis and provided insights on the distribution of lipids in the carotid stenosis. Lipid rich plaques were more often located in the sites with a milder stenosis and smaller plaque burden than at the site of MLA.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

—

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Cardiovascular Imaging

ISSN

1569-5794

e-ISSN

—

Volume of the periodical

32

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

181-188

UT code for WoS article

000367856700020

EID of the result in the Scopus database

2-s2.0-84953837312