Carotid artery plaque composition and distribution: near-infrared spectroscopy and intravascular ultrasound analysis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F20%3A10412699" target="_blank" >RIV/00216208:11130/20:10412699 - isvavai.cz</a>

Alternative codes found

RIV/00064203:_____/20:10412699

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=S7sEG4e6ZM" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=S7sEG4e6ZM</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/eurheartj/suaa097" target="_blank" >10.1093/eurheartj/suaa097</a>

Result language

angličtina

Original language name

Carotid artery plaque composition and distribution: near-infrared spectroscopy and intravascular ultrasound analysis

Original language description

Most atherosclerotic plaques (APs) form in typical predilection areas of low endothelial shear stress (ESS). On the contrary, previous data hinted that plaques rupture in their proximal parts where accelerated blood flow causes high ESS. It was postulated that high ESS plays an important role in the latter stages of AP formation and in its destabilization. Here, we used near-infrared spectroscopy (NIRS) to analyse the distribution of lipid core based on the presumed exposure to ESS. A total of 117 carotid arteries were evaluated using NIRS and intravascular ultrasound (IVUS) prior to carotid artery stenting. The point of minimal luminal area (MLA) was determined using IVUS. A stepwise analysis of the presence of lipid core was then performed using NIRS. The lipid core presence was quantified as the lipid core burden index (LCBI) within 2 mm wide segments both proximally and distally to the MLA. The analysed vessel was then divided into three 20 mm long thirds (proximal, middle, and distal) for further analysis. The maximal value of LCBI (231.9 +- 245.7) was noted in the segment localized just 2 mm proximally to MLA. The mean LCBI in the middle third was significantly higher than both the proximal (121.4 +- 185.6 vs. 47.0 +- 96.5, P &lt; 0.01) and distal regions (121.4 +- 185.6 vs. 32.4 +- 89.6, P &lt; 0.01). Lipid core was more common in the proximal region when compared with the distal region (mean LCBI 47.0 +- 96.5 vs. 32.4 +- 89.6, P &lt; 0.01).

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Heart Journal: Supplements

ISSN

1520-765X

e-ISSN

—

Volume of the periodical

22

Issue of the periodical within the volume

Suppl F

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

"F38"-"F43"

UT code for WoS article

000577169200006

EID of the result in the Scopus database

2-s2.0-85101002740