Near-infrared spectroscopy derived indexes as a potential predictor of plaque burden volume progression after unprotected left main coronary artery intervention

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F25%3A00081711" target="_blank" >RIV/65269705:_____/25:00081711 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/25:00142324

Result on the web

<a href="https://e-coretvasa.cz/artkey/cor-202501-0001_near-infrared-spectroscopy-derived-indexes-as-a-potential-predictor-of-plaque-burden-volume-progression-after-u.php" target="_blank" >https://e-coretvasa.cz/artkey/cor-202501-0001_near-infrared-spectroscopy-derived-indexes-as-a-potential-predictor-of-plaque-burden-volume-progression-after-u.php</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.33678/cor.2025.010" target="_blank" >10.33678/cor.2025.010</a>

Result language

angličtina

Original language name

Near-infrared spectroscopy derived indexes as a potential predictor of plaque burden volume progression after unprotected left main coronary artery intervention

Original language description

Background: Coronary artery disease (CAD) is the leading cause of death worldwide, which has driven significant advances in the field of interventional cardiology. The combination of intravascular ultrasound (IVUS) and near-infrared light spectroscopy (NIRS) offers a detailed view of coronary artery morphology and plaque composition. This advanced imaging capability facilitates a more accurate assessment of CAD and enhances therapeutic strategies. Objective: NIRS can detect and quantify lipid content in atherosclerotic plaque using the Lipid Core Burden Index (LCBI) and the Maximal Lipid Core Burden Index in a 4 mm segment (maxLCBI4mm). In this study, we examined the relationship between these indices and atherosclerotic plaque progression in the crucial area of the left main coronary artery (LM) during a follow-up period of 9 to 12 months after percutaneous coronary interventions (PCI). Methods: A prospective, single-centre study was conducted involving 27 patients with significant left main stenosis who underwent IVUS-NIRS guided PCI. Serial assessments of the LCBI, maxLCBI4mm, and IVUS-derived plaque volume (PV) were performed at baseline, immediately post-PCI, and during follow-up at 9 to 12 months in 18 patients. Results: The mean age of the study population was 72.7 years, with a predominance of male patients (88%). The average LCBI of the LM coronary artery before PCI was 128.9 +/- 122.0, while maxLCBI4mm was 263.7 +/- 172.0. The IVUS-measured PV post-PCI was 418.7 +/- 203.3 mm3, increasing to 454.5 +/- 209.4 mm3 at follow-up (p = 0.105). Analysis revealed no significant correlation between the difference in PV and baseline LCBI or maxLCBI4mm, with p-values of 0.626 and 0.786, respectively. Conclusion: This study found no significant association between initial LCBI and maxLCBI4mm segment values and subsequent changes in PV in the left main coronary artery. However, correlation graphs indicate a trend toward decreased PV in patients with high initial LCBI and maxLCBI4mm.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cor et Vasa

ISSN

0010-8650

e-ISSN

1803-7712

Volume of the periodical

67

Issue of the periodical within the volume

1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

10

Pages from-to

6-15

UT code for WoS article

001437248700001

EID of the result in the Scopus database

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