Mitochondrial Respiration in the Platelets of Patients with Alzheimer's Disease

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F16%3A10327724" target="_blank" >RIV/00216208:11110/16:10327724 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/16:10327724

Result on the web

<a href="http://dx.doi.org/10.2174/1567205013666160314150856" target="_blank" >http://dx.doi.org/10.2174/1567205013666160314150856</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/1567205013666160314150856" target="_blank" >10.2174/1567205013666160314150856</a>

Result language

angličtina

Original language name

Mitochondrial Respiration in the Platelets of Patients with Alzheimer's Disease

Original language description

Mitochondrial dysfunctions significantly contribute to the pathogenesis of Alzheimer's disease (AD). Here, we studied the relationship between AD and changes in the mitochondrial rates of respiration in blood platelets, respiratory chain complexes activity, and coenzyme Q(10) plasma concentrations. In intact platelets obtained from AD patients, we observed a decrease in endogenous basal respiration rates, a decrease in the maximal capacity of the electron transport system (ETS), and higher respiratory rates after inhibiting complex I of the ETS. When normalized for citrate synthase activity, rotenone inhibited respiratory rates and complex I activity was significantly altered. In permeabilized platelets, mitochondrial respiration was completely rescued by the addition of complex I substrates. The changes in mitochondrial respiratory parameters were not associated with the progression of AD except for the capacity of the ETS in permeabilized platelets. In AD, complex I activity was increased, complex IV activity was decreased, and coenzyme Q(10) plasma concentrations were decreased. Our data indicate that both insufficiency in substrates entering into the oxidative phosphorylation system and functional disturbances in the ETS complex are responsible for the decrease in respiration observed in intact platelets in AD patients. Analyses of complex IV activity, the respiratory rates of intact platelets, and the capacity of the ETS in permeabilized platelets may enable the characterization of mitochondrial dysfunctions in the initial stage of AD.

Czech name

—

Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

—

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Current Alzheimer Research

ISSN

1567-2050

e-ISSN

—

Volume of the periodical

13

Issue of the periodical within the volume

8

Country of publishing house

AE - UNITED ARAB EMIRATES

Number of pages

12

Pages from-to

930-941

UT code for WoS article

000380948200011

EID of the result in the Scopus database

2-s2.0-84975783236