Polymorphisms in Non-coding RNA Genes and Their Targets Sites as Risk Factors of Sporadic Colorectal Cancer
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F16%3A10328435" target="_blank" >RIV/00216208:11110/16:10328435 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11140/16:10328435
Result on the web
<a href="http://dx.doi.org/10.1007/978-3-319-42059-2_7" target="_blank" >http://dx.doi.org/10.1007/978-3-319-42059-2_7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-3-319-42059-2_7" target="_blank" >10.1007/978-3-319-42059-2_7</a>
Alternative languages
Result language
angličtina
Original language name
Polymorphisms in Non-coding RNA Genes and Their Targets Sites as Risk Factors of Sporadic Colorectal Cancer
Original language description
Colorectal cancer (CRC) is a complex disease that develops as a consequence of both genetic and environmental risk factors in interplay with epigenetic mechanisms, such as microRNAs (miRNAs). CRC cases are predominantly sporadic in which the disease develops with no apparent hereditary syndrome. The last decade has seen the progress of genomewide association studies (GWAS) that allowed the discovery of several genetic regions and variants associated with weak effects on sporadic CRC. Collectively these variants may enable a more accurate prediction of an individual's risk to the disease and its prognosis. However, the number of variants contributing to CRC is still not fully explored. SNPs in genes encoding the miRNA sequence or in 3'UTR regions of the corresponding binding sites may affect miRNA transcription, miRNA processing, and/or the fi delity of the miRNA-mRNA interaction. These variants could plausibly impact miRNA expression and target mRNA translation into proteins critical for cellular integrity, differentiation, and proliferation. In the present chapter, we describe the different aspects of variations related to miRNAs and other non-coding RNAs (ncRNAs) and evidence from studies investigating these candidate genetic alterations in support to their role in CRC development and progression.
Czech name
—
Czech description
—
Classification
Type
C - Chapter in a specialist book
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
—
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Non-coding RNAs in Colorectal Cancer
ISBN
978-3-319-42057-8
Number of pages of the result
27
Pages from-to
123-149
Number of pages of the book
251
Publisher name
Springer
Place of publication
Neuveden
UT code for WoS chapter
—