Analysis of Expression Profiles of Genes Involved in F0F1-ATP Synthase Biogenesis During Perinatal Development in Rat Liver and Skeletal Muscle
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F16%3A10329192" target="_blank" >RIV/00216208:11110/16:10329192 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/16:10329192
Result on the web
<a href="http://www.biomed.cas.cz/physiolres/pdf/65/65_597.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/65/65_597.pdf</a>
DOI - Digital Object Identifier
—
Alternative languages
Result language
angličtina
Original language name
Analysis of Expression Profiles of Genes Involved in F0F1-ATP Synthase Biogenesis During Perinatal Development in Rat Liver and Skeletal Muscle
Original language description
During the process of intrauterine mammalian fetal development, the oxygen supply in growing fetus is low. A rapid switch from glycolysis based metabolism to oxidative phosphorylation (OXPHOS) must proceed during early postnatal adaptation to extra uterine conditions. Mitochondrial biogenesis and mammalian mitochondrial F0F1 ATP synthase assembly (complex V, EC 3.6.3.14, ATPase) are complex processes regulated by multiple transcription regulators and assembly factors. Using RNA expression analysis of rat liver and skeletal tissue (Rattus norvegicus, Berkenhout, 1769), we describe the expression profiles of 20 genes involved in mitochondrial maturation and ATP synthase biogenesis in detail between the 16th and 22nd day of gestation and the first 4 days of life. We observed that the most important expression shift occurred in the liver between the 20th and 22nd day of gestation, indicating that the fetus prepares for birth about two days before parturition. The detailed mechanism regulating the perinatal adaptation process is not yet known. Deeper insights in perinatal physiological development will help to assess mitochondrial dysfunction in the broader context of cell metabolism in preterm newborns or neonates with poor adaptation to extra uterine life.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
—
Result continuities
Project
<a href="/en/project/GB14-36804G" target="_blank" >GB14-36804G: Centre of mitochondrial biology and pathology (MITOCENTRE)</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Physiological Research
ISSN
0862-8408
e-ISSN
—
Volume of the periodical
65
Issue of the periodical within the volume
4
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
12
Pages from-to
597-608
UT code for WoS article
000386685600007
EID of the result in the Scopus database
2-s2.0-84997501404